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Thread: Melanotan 1 & 2 Peptide Guide/Walkthrough

  1. #1 9th November 2014 
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    Melanotan 1 & 2 Peptide Guide/Walkthrough

    Overview

    Melanotan 1 and 2 are alpha-melanocyte stimulating hormones (α-MSH) which induces skin pigmentation and thus can reduce UV damage to skin over time.



    Appearance

    Generally peptides come in lyophilized (freeze-dried) form and will appear as a white powder, either as a pellet, small chunks, a ball or as a powder.

    Legality

    Melanotan, and most peptides in general are legal to import, export, own and to use.
    However, the domestic sales of most peptides are restricted to universities and government approved clinical trials.
    This is true for Europe, USA and Australia - other regions may vary.

    Another thing to note here is that bacteriostatic water is a prescription only item in many countries. This includes the UK, some countries in Europe and the USA. Again, I'm unsure about the other countries at this time.
    While not always enforced, and I'm pretty sure it wouldn't go very far, it's worth noting that it is illegal to own.
    Sterile waters, like sodium chloride, are legal in most places.

    Travelling

    Travelling with Melanotan is a frequent question for holiday goers and backpackers, and while slightly more difficult it isn't impossible.
    The first thing to take note of is the fact that carrying Melanotan, as above isn't illegal in many countries, but it is worth checking google first. This also goes for needles and sterile water.
    If you can transport all of your supplies its best to prepare it while in your hotel/apartment and store it in a minifridge or similar there, in accordance with the information below. Always pack this into you checked/hold luggage, rather than your carry on/cabin bag.

    If however you can't transport it all or you are backpacking you have a few other options.
    First, you'll have to use bacteriostatic water when mixing at home, sodium chloride is completely unsuitable for this application.
    This should be suitable for travel to a lot more places, if asked just state it's normal sterile water (legal) rather than bacteriostatic water (illegal).

    If the area you are travelling to does not allow Melanotan then you become slightly more limited again. However, the most used option is to transfer the contents of your Melanotan vial into a Vitamin B12 vial. B12 injections are legal in many more countries, again, check first. If B12 is illegal you can search for another similar option.
    Lastly, you will have to go down the nasal route. Purchase a standard nasal mist spray from a supermarket, prepare it as stated below and put it into your hold luggage. If this gets picked up they can look at it, smell it, spray it and test it - it'll be okay.
    Airports don't have the equipment to test for peptides, they are looking for things like amphetamines, barbitrates, benzodiazepines, cocaine, methadone, methaqualone and opiods.

    Storage
    Peptides
    For the sake of continuity;
    Room temperature = (21 - 24C) OR (70 - 75F)
    Refrigerated = (2 - 8C) OR (36 - 43F)
    Freezer = (<-18C) OR (<0F)

    When in freeze dried form they can be stored in many ways;
    Room temperature – 12 months
    Refrigerated – 48 months
    Freezer – 48 months+

    When reconstituted with sodium chloride it can be stored either;
    Room temperature – Not recommended*
    Refrigerated – 1 month
    Freezer – 48 months

    When reconstituted with bacteriostatic water it should be stored;
    Room temperature – 2 months
    Refrigerated – 48 months
    Freezer – Not recommended**

    * Sodium chloride contains no bacteriostatic agent and thus bacteria can flourish in this environment and become toxic within hours.

    ** Some bacteriostatic agents can be denatured from low temperatures and as such should not undergo freeze-thaw cycles.

    Sterile Water
    You should store any unopened sodium chloride and bacteriostatic water in the refrigerator. Opened sodium chloride should be disposed of after first use.

    Other Supplies
    Syringes and alcohol swabs can be stored in any location.

    Dosage Information
    Melanotan 1
    Melanotan 1 has a half life of ~1 hour, this means to get the most out of it you should inject twice daily, once in the morning and then again midday or before UV exposure. It is also better to dose every single day - this adds up to a lot of injections.
    Recommend dosages starting from 1mg (500mcg twice daily) for Melanotan 1 due to the lower side effects associated with it. After 2-4 days increase to 1.5mg (750mcg twice daily) and stick at this point. If you wish to increase the dose further, do so slowly.

    Melanotan 2
    Melanotan 2 has a half life of ~33 hours, this allows you to be very flexible with dosing. However, it will always be better to inject in the morning or midday if getting natural UV exposure. If you are using sunbeds then inject about 20 minutes before exposure. Recommended dosages start at 250mcg every day to help your body acclimatize to the peptide and minimize the side effects. You can continue with this dose indefinitely if you are intending to do a low dosage regimen.
    If you want to dose higher, after 2-4 days, whenever you feel comfortable, up the dose to 500mcg and stick at this point. You can increase the dose as far as about 1mg but any higher is generally not advised.

    UV EXPOSURE
    Sun exposure is recommended to start off slow to ensure that a tan develops before exposing yourself to long intensive sessions. The goal here is to be patient, know your skins limits and to never burn.
    If you live in a sunny area then you can begin slowly exposing yourself outside from the day you begin dosing. Remember to use suncream if you need it and be cautious.
    If you live in an area with low UV exposure or its winter you can visit the sun beds once or twice weekly, depending on your goals. Normally 5-10 minutes is adequate, again follow the advice above and don't push it too far.

    Maintenance
    Once you have reached your desired level of tan then you can enter what is known as the 'maintenance phase'.
    Although the level is different for most people it levels out at around 500mcg every 3 or 4 days and a sunbed session with every or every other dose.
    This will allow you to maintain your tan through winter without much work.

    If you notice at any point you're becoming darker, reduce the dose. If you notice you are getting lighter, add in an extra dose or take up the second sunbed session if you didn't already.

    Side effects
    Generally the side effects fall into the mild category, however there are a few side effects which can be severe but you should only encounter these if you are overdosing.
    If at any point you believe the side effect to be severe, check you didn't overdose. If you didn't then lower your doses slightly and see if that rectifies the issue - your body will react differently based on many things such as an increase/decrease in weight or hormones.
    If they still do not subside then discontinue use. If problems persist then seek medical advice.

    The most common side (from about 50mcg onward) is facial flushing. This is an antibody response to a foreign body and will subside quickly. Generally the effects become unnoticeable after about a week of usage.
    Most of these effects can be mitigated by antihistamines.
    Anything listed below in 'common' is fine to experience, you should keep checks on moles and freckles, though.
    Anything in the 'uncommon' generally means you've overdosed. You can try lowering your dosage or inject half as much twice a day, spreading out the absorption of the peptide.
    Although people class nausea from MT2 as a common thing, it really shouldn't be. Generally this is because people dose too much too fast.
    You may get a slight unease but if it is unbearable to experience through the day, lower your dosage. Injecting before bed is a last resort but can be an effective way of minimizing the nausea if you have no other options.

    Melanotan 1
    Common: Flushing, appetite suppression, darkening of moles.
    Uncommon: Lethargy, nausea, dizziness.

    Melanotan 2
    Common: Flushing, appetite suppression, increased libido, facial hair darkening, darkening of moles.
    Uncommon: Lethargy, nausea, dizziness.

    Hair Darkening
    As hair darkening is a very important side effect of melanotan I've given it it's own section.
    Many people will try melanotan for this effect on its own, however, it can be difficult to maintain good results.

    After starting melanotan you'll start to notice results in about 2 weeks.
    I'll reference the Fitzpatrick scale here.
    Type 2+ will get consistent results when injecting upwards of 500mcg per day.
    Type 1 will normally need upwards of 1mg per day.
    This will obviously lead to you becoming very tanned which you may not desire.
    Attached Images Attached Images
    Last edited by peptideguru; 1st September 2015 at 06:50 AM. Reason: Repairing formatting after domain move
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  3. #2 9th November 2014 
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    Melanotan 1 & 2 Peptide Guide/Walkthrough

    Reconstitution

    This is the act of dissolving your freeze dried powder into a sterile liquid medium ready for injection or into a spray for nasal administation.
    This can be accomplished with either sodium chloride or bacteriostatic water.

    Injection

    There isn't much to consider here except dosage.
    If you wish to use doses of less than 500mcg it would be best to use 2ml (200 units) of water.
    If you wish to use doses of 500mcg or more then you can use 1ml (100 units).
    This allows you to accurately measure doses while not having to inject more fluid than required.

    First, gather your supplies;
    1 Vial of Melanotan
    1 Vial/ampule of Wwter
    1 Insulin syringe
    1 Alcohol swab

    1 Take your Melanotan vial and pop off the top of the vial to reveal the rubber stopper. Wipe with the swab.
    2 If using bacteriostatic water, pop off the top of the vial (if applicable) to reveal the rubber stopper. Wipe with the swab.
    If using sodium chloride, twist off the top of the ampule
    3 Next insert a syringe into the vial/ampule and hold it upside down.
    4 Withdraw your water and inject it slowly into the Melanotan vial aiming at the side, not the powder. This make take several attempts based on the size of your syringes.
    5 Place in the fridge for a few hours or overnight while the powder dissolves, you can swirl or tilt the vial to help. Some residue may remain.

    For Nasal

    This can be accomplished in many ways, the most used method is to mix the freeze dried peptide with sterile water and then transfer it into the nasal spray bottle.
    However, you can mix it with an over the counter nasal mist which can allow for better use.
    If using this and the mixture is thin then you can substitute the water and just remove some from this to reconstitute.

    First, gather your supplies;
    1 Vial of Melanotan
    1 Vial/ampule of Wwter
    1 Insulin syringe
    1 Nasal spray bottle

    1 Take your Melanotan vial and pop off the top of the vial to reveal the rubber stopper.
    2 If using bacteriostatic water, pop off the top of the vial (if applicable) to reveal the rubber stopper. Wipe with the swab.
    If using sodium chloride, twist off the top of the ampule
    3 Next insert a syringe into the vial/ampule and hold it upside down.
    4 Withdraw 50 units of water and inject it slowly into the Melanotan vial aiming at the side, not the powder.
    5 Place in the fridge for a few hours or overnight while the powder dissolves, you can swirl or tilt the vial to help. Some residue may remain.
    6 Insert the syringe again and turn upside down.
    7 Withdraw all of the liquid and remove the syringe.
    8 Unscrew the cap of your nasal spray and slowly inject the liquid into the bottle.
    9 If using an empty bottle you can now transfer the remainder of the water. Wait 2 hours before use.

    Administration

    Overview


    Here you need to consider your dosage again. I’ll be using the figures I stated earlier.

    If you reconstituted with 1ml of water every unit is 100mcg of Melanotan.
    If you want to dose 500mcg, you need 5 units.
    If you want to dose 1000mcg, you need 10 units.

    If you reconstituted with 2ml of water every unit is 50mcg of Melanotan.
    If you want to dose 100mcg, you need 2 units.
    If you want to dose 250mcg, you need 5 units.
    If you want to dose 500mcg, you need 10 units.

    Depending on the size of your needles the scale on the needle can change. The most common two are as follows.





    You also need to consider your injection site, the most popular is the stomach, followed by the leg and buttocks.




    If you have a low body fat percentage you may have to inject at a 45 degree angle or use short needles.
    If you can pinch a small amount of fat then you can inject at a 90 degree angle.



    Pre-loading

    Pre-loading can be advantageous when using sodium chloride or if you wish to save time later.
    This is the best method for when using sodium chloride as it eliminates risk of contamination.

    Gather your supplies;
    1 Vial of reconstituted Melanotan
    All of your syringes.
    3/4 Alcohol wipes
    1 Start by wiping your Melanotan stopper and then insert the syringe.
    2 Turn the vial upside down and withdraw your required dose.
    3 Return the right way up and remove the syringe.
    4 Carefully replace the cap.
    5 Repeat for all of your syringes. If your swab becomes dry then replace it, one swab should manage about 10 syringes
    6 Place your syringes in a zip lock bag and place in the freezer.
    1 When ready to administer your dose take a syringe out of the fridge and allow to thaw, this should only take a few minutes.
    You can hold it in your hand to speed up the process.
    2 Find a suitable injection site and wipe with the alcohol swab.
    3 nsert the needle into your skin in a firm and swift movement.
    4 Slowly push the plunger until all the liquid is gone.
    5 Remove the needle in a similar fashion as above and dispose.
    6 A small amount of blood can be expected, just use the swab to give it another wipe.

    Normal injections

    This is the easiest method and is advised when using bacteriostatic water.
    You can use this method with sodium chloride, however, you must ensure the vials are kept sterile at all times.
    The smallest amount of bacteria can multiply to harmful levels in hours to days depending on storage.

    Gather your supplies;
    1 Vial of reconstituted Melanotan
    All of your syringes.
    3/4 Alcohol wipes
    1 Start by wiping your Melanotan stopper and then insert the syringe.
    2 Turn the vial upside down and withdraw your required dose.
    3 Return the right way up and remove the syringe.
    4 Find a suitable injection site and wipe with the alcohol swab.
    5 Insert the needle into your skin in a firm and swift movement.
    6 Slowly push the plunger until all the liquid is gone.
    7 Remove the needle in a similar fashion as above and dispose.
    8 A small amount of blood can be expected, just use the swab to give it another wipe.
    Last edited by peptideguru; 1st September 2015 at 06:10 AM. Reason: Updating Formatting
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  5. #3 9th November 2014 
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough [WIP]

    ChangeLog

    I'll be listing all changes to the first posts here so that latter posts don't look out of place referencing old/missing content. It also helps keep record of how the guide develops.

    [09.11.14] 13:50 - Added dosage and side effect information.
    [11.11.14] 14:25 - Added travelling/legal information.
    [13.11.14] 00:30 - Added UV exposure information.
    [14.11.14] 17:30 - Added skin type 1 information for hair darkening.

    [05.08.15] 18:25 - Modified guide to work with new forum formatting. Converted lists into tables to increase readability.
    [01.09.15] 07:15 - Added missing sections broken in changeover.
    Last edited by peptideguru; 1st September 2015 at 06:11 AM.
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  7. #4 9th November 2014 
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    Thanks, Tom. It's very useful. The bac water really makes a difference, you can go backpacking for three weeks and keep it out of the fridge in another type of bottle. The thing is: a lot of suppliers just add "water for injections" and then you're never sure what exactly you're using.
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    Excellent write up Tom!. Definitely deserves a sticky. As far as improvements it might be worth going further in detail about side effects and perhaps having a paragraph about the infamous moles on the eye issue. Another useful tidbit would be about legal concerns in EU and the USA.
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    Excellent write up Tom!. Definitely deserves a sticky. As far as improvements it might be worth going further in detail about side effects and perhaps having a paragraph about the infamous moles on the eye issue. Another useful tidbit would be about legal concerns in EU and the USA.
    That's great! I'll start writing it up shortly.

    [hr]

    Thanks, Tom. It's very useful. The bac water really makes a difference, you can go backpacking for three weeks and keep it out of the fridge in another type of bottle. The thing is]
    It's unfortunate that some people are misleading with their products to make them seem more than they're worth. This can lead to even worse issues later down the road it they get poisoned from mislabelled water.

    Tom
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    Yes, to be very sure, it's* best to order bac water from a reliable source.

    Some info on the legal part would be great like]Of course you need to justify your syringe usage but as I once mentioned before, you can take over the counter injectables with you, over here you can get vitamin B12 over the counter.
  11. #8 11th November 2014 
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    Yes, to be very sure, it's* best to order bac water from a reliable source.

    Some info on the legal part would be great like]Of course you need to justify your syringe usage but as I once mentioned before, you can take over the counter injectables with you, over here you can get vitamin B12 over the counter.
    I'm not entirely sure on the law for customs (does it vary?), but I'd imagine if it's legal to import/export via traditional means it would also be legal to carry through the border/airport.
    The only issue would be carrying bacteriostatic water with you without a prescription, this is illegal. You could just mix the vial before hand though.


    Syringes are legal in most countries so shouldn't be an issue. Put them in your checked luggage, not carry on.


    I'll add a travel section soon.


    Tom
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    That's why I mentioned: mix it before with bac water and store it in another type of bottle ( with bac water there shouldn't be a chance that there is bacteria growth I thought) just to avoid the question: what's the type of water you mixed your melanotan with? Of course you will be fine most of the time but you never know that you can eventually save one or two people from getting in trouble.
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    That's why I mentioned]
    I'd probably sterilize the bottle beforehand to be sure though just to be safe.
    I saw before that somebody had bought a vit B12 vial, removed the contents and then moved the MT into the empty B12 vial. That way everything remains sterile and looks like something that's legal in pretty much all places.
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    How do you sterilize a bottle ( of nose spray for instance)
    Over here the B12 I got was sold in breakable glass ampoules and transparent red. Maybe not all B12 liquid is sold that way.
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    How do you sterilize a bottle ( of nose spray for instance)
    Over here the B12 I got was sold in breakable glass ampoules and transparent red. Maybe not all B12 liquid is sold that way.
    You can buy basic sterilization liquid/tablets (Milton, for example) usually for babies bottles, that will work.


    Ah, that could be problematic! I have had b12 in a similar (although bigger, 10ml I believe) multi-use vial. It was also a red colour, as cyanocobalamin and methylcobalamin, the most used B12 compounds are red. However, the vials are normally slightly tinted brown due to the compound's sensitivity to light, kind of similar to the image below.


  16. #13 13th November 2014 
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    I've added a contents list and back to top linking, let me know if you find this useful!


    Tom
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    Thanks, Tom. I really appreciate this.
    When travelling, I was thinking]Another question would be: what it it freezes ( the bac water plus melanotan) on the airplane or at your destination, would that be a major issue as you state it's not recommended to put M2 in the freezer with bac water.
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    Thanks, Tom. I really appreciate this.
    When travelling, I was thinking]Another question would be: what it it freezes ( the bac water plus melanotan) on the airplane or at your destination, would that be a major issue as you state it's not recommended to put M2 in the freezer with bac water.
    Large aeroplanes are sealed and pressurized, this includes the cargo holds, although they don't get directly heated they should maintain temperatures of ~20C from the cabin heat which is also how you can carry pets.


    Unless you're going backpacking in sub zero it shouldn't be too much of an issue.
    But if you are taking it with you a country where it drops below 0C outside then it will be fine until you get to your hotel, if it's still
  19. #16 13th November 2014 
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    I'm glad to see you added a section about UV exposure. Far too many people believe the simply having MT2 in your body protects you from the sun, while anyone who's done their research knows that it is the darkened skin that protects you.
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    Great info! thanks
  21. #18 13th November 2014 
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    I'm glad to see you added a section about UV exposure. Far too many people believe the simply having MT2 in your body protects you from the sun, while anyone who's done their research knows that it is the darkened skin that protects you.
    Yeah, I've seen it a couple of times here when people say they've burned after a X (usually very long) hour sun session but have loaded X amount of MT2 over the last week and they thought it'd be fine. This sort of thing usually does much more damage than good and often puts people off.


    I'm slowly going through the last few months of threads and just adding little bits to this one if I think it important. Although I like some of the questions, some of the more basic ones do get asked quite often. Hopefully this could be a go to option for basic information!


    [hr]


    Great info! thanks
    Glad you like it!
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    Perhaps a section about obtaining supplies other than mt2 would be good? I remeber being very nervous about getting syringes...
  23. #20 14th November 2014 
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    Re: Melanotan 1 & 2 Peptide Guide/Walkthrough

    Perhaps a section about obtaining supplies other than mt2 would be good? I remeber being very nervous about getting syringes...
    I may add a part about over the counter supplies. I can't mention much more than 'you can order online' which people know due to the advertising rules on the forum.
    Unless there was anything else you could think of me adding? I saw a table showing which states syringes are legal in, that could be useful.

    Tom