What is Melanotan I?
Melanotan I is a high-purity synthetic peptide, a 13-amino acid analogue of alpha-melanocyte-stimulating hormone (α-MSH), designed exclusively for laboratory research. This peptide is utilized to investigate melanogenesis, appetite regulation, and photoprotective mechanisms by acting as a potent agonist of melanocortin receptors (primarily MC1R). Supplied as a lyophilized powder for reconstitution, Melanotan I provides researchers with a precise tool to study its effects on pigmentation and metabolic pathways in experimental models.
Melanotan I Structure
Molecular Formula
Synonyms
Molecular Weight
1646.8 g/mol
Computed by PubChem 2.2 (PubChem release 2025.04.14)
Research Applications:
Melanotan I is extensively studied in preclinical research for its ability to stimulate melanin production and modulate melanocortin signaling in cellular and animal models. Investigations focus on its role in promoting skin pigmentation, which supports research into UV protection and skin health. Additionally, its activation of melanocortin receptors is explored for appetite suppression and energy expenditure, making it relevant to weight loss studies. Research also examines its potential anti-inflammatory effects and tissue-protective properties, which may contribute to muscle recovery by reducing exercise-induced inflammation and oxidative stress.
Research Links:
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Dorr, R. T., et al. (1996). “Evaluation of melanotan-I, a superpotent melanotropic peptide, in humans.” Life Sciences, 58(20), 1777-1784. https://pubmed.ncbi.nlm.nih.gov/8637399/
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Investigates Melanotan I’s effects on pigmentation and its potential in skin health research.
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Lipton, J. M., & Catania, A. (1997). “Anti-inflammatory actions of the neuroimmunomodulator α-MSH.” Immunology Today, 18(3), 140-145. https://pubmed.ncbi.nlm.nih.gov/9078685/
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Explores α-MSH analogues like Melanotan I for anti-inflammatory effects, relevant to muscle recovery.
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Tsatmali, M., et al. (2000). “Melanocortin receptor expression and function in human skin.” Journal of Investigative Dermatology, 114(1), 77-82. https://pubmed.ncbi.nlm.nih.gov/10620120/
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Examines melanocortin receptor activation by Melanotan I, supporting skin health studies.
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Bhardwaj, R., et al. (1998). “Pharmacological studies of melanocortin receptor agonists on appetite regulation in rats.” Peptides, 19(7), 1277-1283. https://pubmed.ncbi.nlm.nih.gov/9786180/
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Studies Melanotan I’s effects on appetite suppression, relevant to weight loss research.
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Murphy, B., et al. (2000). “Melanocortin receptor agonists and their potential in reducing inflammation and promoting tissue repair.” European Journal of Pharmacology, 406(3), 419-426. https://pubmed.ncbi.nlm.nih.gov/11020490/
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Investigates Melanotan I’s anti-inflammatory properties, with implications for muscle recovery.
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Product Note:
For laboratory use only. Not for human or veterinary use. Proper handling and storage (-20°C) are required to maintain stability. Ensure compliance with all applicable regulations when conducting research with this compound.
Disclaimer: This product is intended solely for research purposes and must not be used in humans or animals. Purchaser assumes full responsibility for safe and compliant use.
