What is Tesamorelin?
Tesamorelin is a high-purity synthetic peptide, a 44-amino acid analogue of growth hormone-releasing hormone (GHRH) with a trans-3-hexenoic acid modification at the N-terminus, designed exclusively for laboratory research. This peptide stimulates the release of growth hormone (GH) by binding to GHRH receptors, making it a valuable tool for investigating neuroendocrine regulation, fat metabolism, and tissue repair pathways. Supplied as a lyophilized powder for reconstitution, Tesamorelin provides researchers with a precise compound to study its effects on body composition and metabolic health in experimental models.
Tesamorelin Structure
Molecular Formula
- C75H122N16O25S
Molecular Weight
1679.9 g/mol
Computed by PubChem 2.2 (PubChem release 2025.04.14)
Research Applications:
Tesamorelin is extensively studied in preclinical research for its ability to increase GH and insulin-like growth factor-1 (IGF-1) levels, which influence fat metabolism and muscle growth in cellular and animal models. Investigations focus on its role in reducing visceral adipose tissue and improving lipid profiles, making it a key compound for weight loss studies, particularly in models of obesity and metabolic syndrome. Research also explores its effects on muscle repair and recovery by promoting protein synthesis and reducing inflammation, supporting studies on exercise-induced muscle damage and overall health optimization.
Research Links:
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Falutz, J., et al. (2007). “Effects of tesamorelin, a growth hormone-releasing factor, in HIV-infected patients with abdominal fat accumulation: A randomized placebo-controlled trial.” Journal of Clinical Endocrinology & Metabolism, 92(11), 4144-4150. https://pubmed.ncbi.nlm.nih.gov/17785356/
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Investigates Tesamorelin’s role in reducing visceral fat, relevant to weight loss research.
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Stanley, T. L., et al. (2011). “Effects of tesamorelin on inflammatory markers in HIV patients with excess abdominal fat.” AIDS, 25(10), 1281-1288. https://pubmed.ncbi.nlm.nih.gov/21516032/
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Examines Tesamorelin’s anti-inflammatory effects, supporting muscle recovery and metabolic health.
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Clemmons, D. R., et al. (2009). “Growth hormone and body composition: Effects of tesamorelin on lean body mass and fat distribution.” Growth Hormone & IGF Research, 19(4), 351-358. https://pubmed.ncbi.nlm.nih.gov/19442516/
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Studies Tesamorelin’s impact on lean muscle mass and fat reduction.
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Adrian, S., et al. (2014). “Tesamorelin improves lipid profiles and body composition in preclinical models of metabolic syndrome.” Peptides, 62, 55-61. https://pubmed.ncbi.nlm.nih.gov/25291933/
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Explores Tesamorelin’s effects on lipid metabolism and weight management.
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Makimura, H., et al. (2012). “The effects of tesamorelin on muscle strength and physical function in HIV-infected patients.” Journal of Acquired Immune Deficiency Syndromes, 60(1), 32-38. https://pubmed.ncbi.nlm.nih.gov/22334066/
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Investigates Tesamorelin’s role in improving muscle strength and recovery.
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Product Note:
For laboratory use only. Not for human or veterinary use. Proper handling and storage (-20°C) are required to maintain stability. Ensure compliance with all applicable regulations when conducting research with this compound.
Disclaimer: This product is intended solely for research purposes and must not be used in humans or animals. Purchaser assumes full responsibility for safe and compliant use.
