What is LL-37?
LL-37 is a high-purity synthetic peptide, a 37-amino acid cationic antimicrobial peptide derived from the human cathelicidin hCAP-18, designed exclusively for laboratory research. This peptide is utilized to investigate antimicrobial, immunomodulatory, and tissue repair mechanisms. Supplied as a lyophilized powder for reconstitution, LL-37 provides researchers with a robust tool to study its effects on infection control, inflammation, and regenerative processes in experimental models.
LL-37 Structure
Molecular Formula
Synonyms
Molecular Weight
4493 g/mol
Computed by PubChem 2.2 (PubChem release 2025.04.14)
Research Applications:
LL-37 is extensively studied in preclinical research for its antimicrobial and immunomodulatory properties, which support overall health by combating microbial infections and regulating immune responses in cellular and animal models. Investigations focus on its role in promoting wound healing and tissue repair, critical for muscle recovery after injury or exercise-induced damage. Research also explores its potential to modulate inflammation, which may indirectly support weight management by addressing obesity-related chronic inflammation. Its ability to stimulate angiogenesis and collagen synthesis makes LL-37 a key compound for studying muscle repair, immune health, and metabolic homeostasis.
Research Links:
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Dürr, U. H., et al. (2006). “LL-37, the only human member of the cathelicidin family of antimicrobial peptides.” Biochimica et Biophysica Acta (BBA) – Biomembranes, 1758(9), 1408-1425. https://pubmed.ncbi.nlm.nih.gov/16716248/
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Reviews LL-37’s antimicrobial and immunomodulatory roles, relevant to health and tissue repair.
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Heilborn, J. D., et al. (2003). “The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium.” Journal of Investigative Dermatology, 120(3), 379-389. https://pubmed.ncbi.nlm.nih.gov/12603850/
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Investigates LL-37’s role in wound healing, applicable to muscle recovery research.
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Ramos, R., et al. (2011). “Wound healing activity of the human antimicrobial peptide LL-37.” Peptides, 32(7), 1469-1476. https://pubmed.ncbi.nlm.nih.gov/21693124/
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Examines LL-37’s effects on tissue repair and regeneration, supporting muscle recovery studies.
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Scott, M. G., et al. (2002). “The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses.” Journal of Immunology, 169(7), 3883-3891. https://pubmed.ncbi.nlm.nih.gov/12244192/
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Explores LL-37’s immunomodulatory effects, relevant to health and inflammation control.
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Shaykhiev, R., et al. (2014). “Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure.” American Journal of Physiology – Lung Cellular and Molecular Physiology, 287(6), L1157-L1163. https://pubmed.ncbi.nlm.nih.gov/15347564/
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Studies LL-37’s role in cell proliferation and tissue repair, with implications for muscle recovery.
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Product Note:
For laboratory use only. Not for human or veterinary use. Proper handling and storage (-20°C) are required to maintain stability. Ensure compliance with all applicable regulations when conducting research with this compound.
Disclaimer: This product is intended solely for research purposes and must not be used in humans or animals. Purchaser assumes full responsibility for safe and compliant use.
