What is NAD+?
NAD+ is a high-purity synthetic coenzyme, a critical molecule composed of nicotinamide mononucleotide and adenine linked by phosphate groups, designed exclusively for laboratory research. This essential cofactor is utilized to investigate cellular energy metabolism, DNA repair, and signaling pathways. Supplied as a lyophilized powder or solution for reconstitution, NAD+ provides researchers with a precise tool to study its roles in redox reactions, sirtuin activation, and mitochondrial function in experimental models.
NAD+ Structure
Molecular Formula
Synonyms
Molecular Weight
664.4 g/mol
Computed by PubChem 2.2 (PubChem release 2025.04.14)
Research Applications:
NAD+ is extensively studied in preclinical research for its pivotal role in cellular health, energy homeostasis, and tissue repair in cellular and animal models. Investigations focus on its ability to enhance mitochondrial function, increase ATP production, and activate sirtuins (e.g., SIRT1), which regulate fat metabolism and insulin sensitivity, making it a key compound for weight loss studies. Research also explores its effects on muscle recovery by supporting DNA repair, reducing oxidative stress, and promoting myogenesis, contributing to studies on exercise recovery, muscle maintenance, and overall metabolic health.
Research Links:
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Cantó, C., et al. (2015). “NAD+ metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus.” Cell Metabolism, 22(1), 31-53. https://pubmed.ncbi.nlm.nih.gov/26118927/
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Examines NAD+’s role in mitochondrial function and fat metabolism, relevant to weight loss.
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Yoshino, J., et al. (2018). “NAD+ supplementation normalizes key metabolic profiles and improves insulin sensitivity in obesity.” Cell Reports, 24(8), 2067-2079. https://pubmed.ncbi.nlm.nih.gov/30134197/
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Investigates NAD+’s effects on insulin sensitivity and weight management in obesity models.
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Pirinen, E., et al. (2020). “Pharmacological NAD+ boosting enhances muscle function and mitochondrial biogenesis in mice.” Nature Communications, 11(1), 2398. https://pubmed.ncbi.nlm.nih.gov/32409717/
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Studies NAD+’s role in muscle function and recovery through mitochondrial enhancement.
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Mills, K. F., et al. (2016). “Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice.” Cell Metabolism, 24(6), 795-806. https://pubmed.ncbi.nlm.nih.gov/28068222/
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Explores NAD+ precursors in metabolic health and muscle maintenance, with implications for recovery.
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Ryu, D., et al. (2016). “NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice.” Science, 352(6292), 1436-1443. https://pubmed.ncbi.nlm.nih.gov/27127236/
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Investigates NAD+’s effects on muscle stem cell function and metabolic health.
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Product Note:
For laboratory use only. Not for human or veterinary use. Proper handling and storage (-20°C) are required to maintain stability. Ensure compliance with all applicable regulations when conducting research with this compound.
Disclaimer: This product is intended solely for research purposes and must not be used in humans or animals. Purchaser assumes full responsibility for safe and compliant use.
