What is SS-31 (Elamipretide)?
SS-31 (Elamipretide) is a high-purity synthetic tetrapeptide, with the sequence D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2′,6′-dimethyltyrosine), designed exclusively for laboratory research. This mitochondria-targeting peptide is utilized to investigate mitochondrial function, oxidative stress mitigation, and cellular protection pathways. Supplied as a lyophilized powder for reconstitution, SS-31 provides researchers with a precise tool to study its effects on energy metabolism and tissue repair in experimental models.
SS-31 (Elamipretide) Structure
Molecular Formula
Molecular Weight
642.5 g/mol
Computed by PubChem 2.2 (PubChem release 2025.04.14)
Research Applications:
SS-31 is extensively studied in preclinical research for its ability to enhance mitochondrial bioenergetics, reduce oxidative stress, and promote tissue repair in cellular and animal models. Investigations focus on its role in improving ATP production and mitochondrial membrane potential, which supports muscle performance and recovery from exercise-induced damage. Research also explores its effects on fat metabolism and insulin sensitivity, making it a key compound for weight loss studies by addressing obesity-related mitochondrial dysfunction. Its anti-inflammatory and cytoprotective properties further support its use in health optimization and muscle repair research.
Research Links:
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Szeto, H. H., et al. (2011). “Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury.” Journal of the American Society of Nephrology, 22(6), 1041-1052. https://pubmed.ncbi.nlm.nih.gov/21546574/
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Investigates SS-31’s role in mitochondrial protection, relevant to muscle recovery.
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Zhao, K., et al. (2004). “Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury.” Journal of Biological Chemistry, 279(33), 34682-34690. https://pubmed.ncbi.nlm.nih.gov/15178689/
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Examines SS-31’s antioxidant effects, supporting muscle and metabolic health.
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Siegel, M. P., et al. (2013). “Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice.” Aging Cell, 12(5), 763-771. https://pubmed.ncbi.nlm.nih.gov/23692570/
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Studies SS-31’s effects on muscle performance and recovery in aging models.
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Escribano-López, I., et al. (2018). “The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes.” Scientific Reports, 8(1), 15862. https://pubmed.ncbi.nlm.nih.gov/30367167/
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Explores SS-31’s role in metabolic health and inflammation, relevant to weight loss.
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Campbell, M. D., et al. (2019). “SS-31 (Elamipretide) improves mitochondrial function and reduces oxidative stress in skeletal muscle of aged mice.” Free Radical Biology and Medicine, 134, 451-459. https://pubmed.ncbi.nlm.nih.gov/30615943/
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Investigates SS-31’s effects on mitochondrial function and muscle recovery.
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Product Note:
For laboratory use only. Not for human or veterinary use. Proper handling and storage (-20°C) are required to maintain stability. Ensure compliance with all applicable regulations when conducting research with this compound.
Disclaimer: This product is intended solely for research purposes and must not be used in humans or animals. Purchaser assumes full responsibility for safe and compliant use.
