What is Humanin?
Humanin is a high-purity synthetic peptide, a 24-amino acid mitochondrial-derived peptide, designed exclusively for laboratory research. Encoded within the mitochondrial 16S rRNA gene, Humanin is used to investigate cytoprotective and metabolic pathways, with a focus on its potential roles in health maintenance, weight regulation, and tissue repair. Supplied as a lyophilized powder for reconstitution, Humanin provides researchers with a precise tool to study its effects on cellular protection, metabolic homeostasis, and muscle recovery in experimental models.
Humanin Structure
Molecular Formula
Synonyms
Molecular Weight
2687.2 g/mol
Computed by PubChem 2.2 (PubChem release 2025.04.14)
Research Applications:
Humanin is extensively studied in preclinical research for its ability to modulate metabolic pathways, protect against oxidative stress, and support tissue repair in cellular and animal models. Research highlights its role in improving insulin sensitivity and glucose metabolism, which are critical for weight management studies. Additionally, Humanin’s anti-apoptotic and anti-inflammatory properties are investigated in models of muscle damage and recovery, where it may mitigate oxidative stress and promote cellular repair. Studies also explore its potential to protect against metabolic dysfunction and support muscle homeostasis, making it a key compound for research into health optimization, weight regulation, and muscle recovery mechanisms.
Research Links:
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Lee, C., et al. (2013). “Humanin: A harbinger of mitochondrial-derived peptides?” Trends in Endocrinology & Metabolism, 24(2), 60-69. https://doi.org/10.1016/j.tem.2012.11.002
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Explores Humanin’s role in mitochondrial function and metabolic regulation, with implications for health and weight management.
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Muzumdar, R. H., et al. (2009). “Humanin: A novel regulator of insulin sensitivity and its potential in type 2 diabetes mellitus.” Diabetes, 58(7), 1538-1546. https://doi.org/10.2337/db09-0270
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Investigates Humanin’s effects on insulin sensitivity and glucose metabolism, relevant to weight regulation research.
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Cobb, L. J., et al. (2016). “Naturally occurring mitochondrial-derived peptides are age-regulated and have anti-apoptotic and insulin-sensitizing effects.” Aging Cell, 15(2), 222-228. https://doi.org/10.1111/acel.12431
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Examines Humanin’s role in metabolic health and its potential to mitigate age-related metabolic decline.
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Sreekumar, P. G., et al. (2016). “The mitochondrial-derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction.” Investigative Ophthalmology & Visual Science, 57(3), 1238-1253. https://doi.org/10.1167/iovs.15-17053
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Studies Humanin’s protective effects against oxidative stress, with implications for muscle cell recovery.
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Zárate, S. C., et al. (2020). “Humanin protects skeletal muscle cells from oxidative stress-induced damage.” Frontiers in Physiology, 11, 570. https://doi.org/10.3389/fphys.2020.00570
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Focuses on Humanin’s role in protecting skeletal muscle cells from oxidative damage, supporting muscle recovery research.
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Product Note:
For laboratory use only. Not for human or veterinary use. Proper handling and storage (-20°C) are required to maintain stability. Ensure compliance with all applicable regulations when conducting research with this compound.
Disclaimer: This product is intended solely for research purposes and must not be used in humans or animals. Purchaser assumes full responsibility for safe and compliant use.
